RMC-9805 (KRAS G12D inhibitor 18)
国际站：RMC-9805 (KRAS G12D inhibitor 18)
CAS：2922732-54-3
纯度：98.90%
分子量：1168.44
Formula：C63H88F3N11O7
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
产品活性：RMC-9805 (KRAS G12D inhibitor 18) 是 KRAS G12D 抑制剂。具有口服有效性。可以抑制 KRAS G12D 突变型癌细胞中的 RAS 信号传导并且诱导细胞凋亡。
生物活性：rmmc -9805 (KRAS G12D inhibitor 18)是KRAS G12D抑制剂[1]。rmmc -9805口服有效。rmmc -9805在KRAS G12D突变癌细胞中抑制RAS信号并诱导凋亡[2]。
参考文献：
[1]. BLAKE JAMES F, et al. Preparation of peptide-linked macrocyclic dipeptides as Ras inhibitors.World Intellectual Property Organization, WO2023060253 A1 2023-04-13
[2]. Knox, J et al.RMC-9805, a first-in-class, mutant-selective, covalent and orally bioavailable KRASG12D(ON) inhibitor, promotes cancer-associated neoantigen recognition and synergizes with immunotherapy in preclinical models. Cancer Res 1 April 2023; 83 (7_Supplement): 3475