Elongin-B, Human, 重组蛋白 (GST)-有机试剂-试剂-生物在线
Elongin-B, Human, 重组蛋白 (GST)

Elongin-B, Human, 重组蛋白 (GST)

商家询价

产品名称: Elongin-B, Human, 重组蛋白 (GST)

英文名称: Elongin-B Protein, Human, Recombinant (GST)

产品编号: TMPH-01288

产品价格: 20 μg

产品产地: 美国

品牌商标: TargetMol

更新时间: 2024-05-23T17:34:14

使用范围: null

规格 价格
1320.00
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SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells.; Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. This includes the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.